DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion

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Several mechanisms have been associated with transcriptional and post-transcriptional regulation of PD-L1 in cancer.Here the Wooden Blocks authors show that a RNA binding protein, DENR, positively regulates the translation of JAK2 and induces PD-L1 expression in tumor cells, associated Cough and Cold Relief with immune evasion.